Prof. Pavel Tchelidze is an acknowledged expert/specialist in cell/tissue biology largely centered on modern microscopy technologies and 3D/4D digital imaging of bio-structures. It should be stressed, that Prof. P. Tchelidze has unique for Georgia experience in living/fixed cells 3D/4D imaging that is reflected in a number of publications performed using corresponding methodologies. He is closely familiar with all modern methods of microscopy (LCM, SHG, SRM, TEM, SEM, MV STEM, cryo-EM, CLEM, cryo-CLEM) and microscopy imaging approaches. As these microscopy imaging approaches are associated with different 3D reconstruction techniques, Prof. P. Tchelidze is the only Georgian specialist who has a long-term familiarity with different methods of 3D optical and electron tomography. His long-term research interest is mainly focused on the 3D nano-structure as well as 4D dynamics of sites of localization and transcription of genes of rRNA (nucleolus). In this respect, since 2000 he has a permanent collaboration with MeDIAN (now corresponding to BioSpecT) Laboratory at Faculty of Pharmacy of University of Reims Champagne-Ardene (URCA, Reims, France). It’s important to mention, that working at URCA on nucleolar 3D nano-architecture and 4D dynamics, he established a fruitful collaboration with the prominent authority in this field – Prof. D. Ploton. Their team succeeded to develop several advanced methods, like: MV STEM 3D reconstruction according tilted sections, conventional CLEM modified by post-fixation immunolabeling and LCM/EM overlay, and all of them – performed on the same cell (one-cell-focused approach). Last several years, Prof. P. Tchelidze’s interests expanded and now include tissue engineering and application of novel artificial polymeric scaffolds for reconstructive and regenerative medicine.
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